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Thomas M Durcan Selected Research

Therapeutics

1/2021Development of an α-synuclein knockdown peptide and evaluation of its efficacy in Parkinson's disease models.
1/2020Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases.
1/2019Patient-Derived Stem Cells, Another in vitro Model, or the Missing Link Toward Novel Therapies for Autism Spectrum Disorders?
1/2018Open Science Meets Stem Cells: A New Drug Discovery Approach for Neurodegenerative Disorders.

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Thomas M Durcan Research Topics

Disease

24Parkinson Disease (Parkinson's Disease)
03/2024 - 01/2011
8Synucleinopathies
10/2023 - 01/2017
7Neurodegenerative Diseases (Neurodegenerative Disease)
04/2024 - 01/2012
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2023 - 01/2020
3Alzheimer Disease (Alzheimer's Disease)
07/2021 - 01/2020
3Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)
01/2013 - 01/2011
2Neoplasms (Cancer)
01/2024 - 01/2020
2Autism Spectrum Disorder
10/2023 - 01/2019
2Dementia (Dementias)
09/2023 - 11/2022
2Frontotemporal Dementia (Semantic Dementia)
01/2023 - 01/2022
2Proteostasis Deficiencies
11/2022 - 01/2022
2Ataxia (Dyssynergia)
01/2013 - 01/2011
1Lysosomal Storage Diseases (Lysosomal Storage Disease)
04/2024
1Neuraminidase 1 deficiency
04/2024
1Mucopolysaccharidoses
04/2024
1Mucopolysaccharidosis III (Sanfilippo Syndrome)
04/2024
1Leukoencephalopathies
04/2024
1Ciliopathies
01/2024
1Inborn Genetic Diseases (Disease, Hereditary)
01/2024
1Disease Progression
10/2023
1Fragile X Syndrome (Martin Bell Syndrome)
10/2023
1Autistic Disorder (Autism)
10/2023
1Lewy Body Disease (Lewy Body Dementia)
09/2023
1Atrophy
11/2022
1Nervous System Diseases (Neurological Disorders)
07/2021
1Glioblastoma (Glioblastoma Multiforme)
11/2020
1Brain Neoplasms (Brain Tumor)
11/2020
1Traumatic Brain Injuries (Traumatic Brain Injury)
01/2020
1Intellectual Disability (Idiocy)
10/2018

Drug/Important Bio-Agent (IBA)

13Proteins (Proteins, Gene)FDA Link
11/2023 - 02/2011
7SynucleinsIBA
11/2023 - 01/2021
6alpha-SynucleinIBA
03/2024 - 01/2022
4Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
03/2015 - 01/2011
3EnzymesIBA
04/2024 - 01/2011
3Glucosylceramidase (Glucocerebrosidase)IBA
03/2024 - 01/2023
3Phosphotransferases (Kinase)IBA
01/2024 - 05/2015
3Ligases (Synthetase)IBA
05/2015 - 01/2013
3Ataxin-3IBA
01/2013 - 01/2011
2HydrolasesIBA
03/2024 - 11/2023
2Cathepsin BIBA
03/2024 - 11/2023
2Deubiquitinating EnzymesIBA
11/2023 - 01/2012
2PrionsIBA
10/2023 - 01/2021
2Biomarkers (Surrogate Marker)IBA
10/2023 - 07/2021
2RNA (Ribonucleic Acid)IBA
09/2023 - 01/2023
2Peptides (Polypeptides)IBA
07/2021 - 01/2021
2polyglutamineIBA
01/2013 - 01/2011
1polysialic acidIBA
04/2024
1Cathepsin AIBA
04/2024
1GalactosidasesIBA
04/2024
1Glycoproteins (Glycoprotein)IBA
04/2024
1GlycosaminoglycansIBA
04/2024
1SulfatasesIBA
04/2024
1Neuraminidase (Sialidase)IBA
04/2024
1Polysaccharides (Glycans)IBA
04/2024
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
04/2024
1PTEN-induced putative kinaseIBA
03/2024
1ChaperoninsIBA
11/2023
1Fragile X Mental Retardation ProteinIBA
10/2023
1RNA-Binding Proteins (RNA-Binding Protein)IBA
10/2023
1Protein AggregatesIBA
09/2023
1c-Mer Tyrosine KinaseIBA
09/2023
1Messenger RNA (mRNA)IBA
09/2023
1DipeptidesIBA
01/2023
1GalactosylceramidaseIBA
01/2023
1C9orf72 ProteinIBA
01/2023
1Molecular Chaperones (Chaperone, Molecular)IBA
11/2022
1Intrinsically Disordered ProteinsIBA
11/2022
1Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
01/2022
1Amyloid beta-PeptidesIBA
07/2021
1Tetracycline (Achromycin)FDA LinkGeneric
07/2021
1Amyloid (Amyloid Fibrils)IBA
01/2021
1Dendrimers (Dendrons)IBA
11/2020
1Conditioned Culture MediaIBA
11/2020
1Sulfates (Sulfates, Inorganic)IBA
11/2020
1polyglycerolIBA
11/2020
1Biocompatible Materials (Biomaterials)IBA
01/2020
1N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10/2018

Therapy/Procedure

4Therapeutics
01/2021 - 01/2018
1Precision Medicine
04/2024